杨文超简介
【个人简介】
杨文超，男，理学博士，研究方向为植物保护、药物分子设计。国务院政府特殊津贴获得者、教育部长江学者特聘教授、中组部万人计划青年拔尖人才计划入选者、宝钢优秀教师奖获得者、香江学者计划入选者；先后荣获第四届全国高校教师教学创新大赛一等奖、贵州省普通本科高校“金师”（教学名师）、贵州省高校教师教学创新大赛一等奖、贵州省教学成果特等奖。现为Journal of Analysis and Testing青年编委，Advanced Biotechnology编委。先后主持国家重点研发计划课题项目、国家自然科学基金面上项目4项，以及多个省部级以上项目。在Trends in Plant Sci、Trends in Anal. Chem.、J. Am. Chem. Soc.、Plant Physiol.、ACS Nano、J. Agric. Food Chem.、Pest Manag. Sci、The FEBS J.、Eur. J. Med. Chem.和Anal.Chem.等国际主流学术期刊上发表相关研究论文80余篇，获中国和国际发明专利授权10项。
邮箱：wcyang@gzu.edu.cn
【主持项目】
1.国家重点研发计划(课题)：高选择性除草剂创制的分子基础与新品种开发（2021YFD1700103），2021/05-2025/12，主持。
2.国家自然科学基金面上项目：靶向茄尼基焦磷酸合酶的选择性除草剂创制的分子基础（32372584）。2024/01-2027/12，主持。
3.国家“万人计划”青年拔尖人才，2022/01-2024/12，220万，主持。
4.国家自然科学基金面上项目：基于小分子探针的线粒体呼吸链复合物II与复合物III的相互作用研究（21977036），2020/01-2023/12，主持。
5.国家自然科学基金面上项目：HPPD的催化反应机理及其与抑制剂相互作用的研究（21672079），2017/01-2020/12，主持。
6.国家自然科学基金面上项目：靶向细胞色素bc1复合物Qi位点的新型杀菌剂的设计与合成（21372094），2014/01-2017/12，主持。
7.国家自然科学基金青年科学基金项目：以细胞色素bc1复合物为靶标的新型杀菌剂的合理设计（21102052）。2012/01-2014/12，主持。
8.湖北省重点研发项目，2020BHB027，优质杂交水稻培育与配套除草剂的筛选与示范。2020/08-2022/07，30万元，主持。
9.广东省科技计划项目，20140107，高效丁酰胆碱酯酶突变体的制备及其在农药残留检测中的应用、2016/01-2017/12，主持。
【学术论文】
1.Gong,X.Y.;Wang, Z.H.; Maria B.; Tang, T.; Gan, X.H.;Yang,W.C.*Recent application of CRISPR/Cas in plant disease detection.Trends in Analytical Chemistry2025,189, 118251.
2.Yang,S.J.;Zhou,B.Y.;Chen, Z.; Li, S.Y.; Kim, Y.J.; Luo, J.; Lee, K.P.; Zhou, Y.; Zhu, L.; Wu, F.X.; Kim, J.S.*;Yang, W. C.*Cavity Filling-Based Enzyme Activatable Luminophores Leveraged In Vivo Bioimaging.J. Agric. Food Chem.2025, 73,17287−17297.
3.Ndikuryayo, F.;Gong,X.Y.;Gan, X.H.*;Yang, W. C.*Assessing emerging contaminants in soils using soil enzyme-based methods: A critical review.Trends in Environmental Analytical Chemistry,2025,46,e00260.
4.Zhang,Z.Y.;Feng, Y.Y.; Luo,J.;Wang, W.; Qiu, X.X.*;Yang,W.C.*A glutathione S-transferase-activated fluorogenic sensor for in vivo plantstress diagnostics.Sensors & Actuators: B. Chemical.2025,432,137456.
5.Elaheh A.; Amirreza N.T.; Maria B.;Yang, W. C.*Plant osmosensors in next-generation smart agriculture: From innovationto application.Industrial Crops & Products.2025,234,121607.
6.Tang, T.;Ndikuryayo, F.;Gong,X.Y.;Elaheh, A.; Mehtab M.A.; Chen, M.X.*;Yang, W. C.*Deciphering the complex roles of leucine-rich repeat receptor kinases(LRR-RKs) in plant signal transduction.Plant Sci.2025,356,112494.
7.Li, Y.X.; Luo, J.;Ndikuryayo, F.;Chen,Y.X.;Liu, G.Z.*;Yang, W. C.*Advances in Fluorescence-based Probes for Abiotic Stress Detectionin Plants.ACS Sens.2025, 10,2474−2486.
8.Li, S.Y.; Gong,X.Y.;Ndikuryayo, F.;Yang, W. C.*The emerging role of oxygen redox in pathological progression of disorders.Ageing Res. Rev.2025,104,102660.
9.Asghar, S.; Yu, Z.Y.; Zhu, Z.; Zheng, D.Y.; Zhao, Z.M.; Xu, Y.M.; Liu, X.; Yuan, C.; Li, Y.; Wang, W.; Xu, J.F.; Teng, HL.; Li, J.*,Yang,W.C.*, Chen, C.L.* Visualization of Hg2+Stress on Plant Health at the Subcellular Level Revealed by a Highly Sensitive Fluorescent Sensor.Research.2025. https://doi.org/10.34133/research.0570.
10.Zhang,Z.Y.;Ndikuryayo, F.;Wang, J.G.*;Yang,W.C.*How to Identify Pesticide Targets?J. Agric. Food Chem.2025, 73,1790-1800.
11.Ndikuryayo, F.;Gong,X.Y.;Yang, W. C.*Advances in Understanding the Toxicity of 4-Hydroxyphenylpyruvate Dioxygenase-Inhibiting Herbicides.J. Agric. Food Chem.2024,72, 17762-17770.
12.Luo, J.; Gong,X.Y.;Zhou, B.Y.; Yang, L.;Yang,W.C.*Advances in Nanohydrolase-based Pollutant Sensing.Trends Environ. Anal. Chem.2024,43, e00238.
13.Zhang,Z.Y.;Yang, Y.;Yang,W.C.*ResearchProgress inBiomarker-TargetedOpticalBiosensors forPlantDiseaseDetection.Trends Anal. Chem.2024,178, 117841.
14.Gong,X.Y.;Haywood, J.*;Yang,W.C.*ChemicalGeneticsApproaches forPesticideTargetMining.Trends Plant Sci.2024, https://doi.org/10.1016/j.tplants.2024.06.004.
15.Huang,F.Y.;Chen, L.; Zhou,Y.;Huang,J.Q.;Wu,F.;Hu,Q.;Chang,N.;Qiu,T.Y.;Zeng,Y.;He,H.R.;White,J.C.;Yang,W.C.*;Fang,L.C.*ExogenousSeleniumPromotesCadmiumReduction andSeleniumEnrichment inRice: Evidence,Mechanisms, andPerspectives.J. Hazard. Mater.2024, 476 ,135043.
16.Li,Y.X.;Zhang, Z.Y.; Li,S.Y.;Gong,X.Y.;Yang,W.C.*Development of Cholinesterase-Activatable Fluorescent Probes forPesticide Residue Detection.ACS Agric. Sci. Technol.2024,4, 337-344.
17.Ju,W.L.;Liu,J.;Yang,W.C.*;Fan,Q.H.;Huang,M.;Fang,L.C.*EnhancingSoilEcologicalSecurity throughPhytomanagement ofTailings inErosion-ProneAreas.J. Hazard. Mater.2024, 462 ,132730.
18.Yang,W.C.*;Li,S.Y.;Ni,S.N.;Liu,G.Z.*Advances in FRET-basedBiosensors fromDonor-acceptorDesigntoApplications. Aggregate.2023, https://doi.org/10.1002/agt2.460.
19.Wu,H.;Li,J.H.;Yang,W.C.;Wen,T.;He,J.;Gao, Y.Y.*; Hao, G.F.*;Yang, W.C.*Nonmetal-dopedQuantumDot-basedFluorescenceSensingFacilitates theMonitoring ofEnvironmentalContaminants.Trends Environ. Anal. Chem.2023.40, e00218.
20.Pang,Y.D.;Liu, M.J.;Rha,H.;Yang, W.C.*;Sharma,A.; Sun, Y.*;Kim, J.S.*In Vivo Lighting Up Plants with Near-Infrared FluorescenceProbes.Sci. China Chem.2023.https://doi.org/10.1007/s11426-023-1815-9
21.Ndikuryayo, F.;Yang, W. C.*New Insights into the Interactions between Herbicides: Trends from Recent Studies.J. Agric. Food Chem.2023,71, 10970−10981.
22.Guo,W.Y.;Fu,Y.X.;Mei, L.C.;Chen, Z.;Zhang,Z.Y;Wang,F.;Yang, W.C.*;Liu,G.Z.*; Yang, G.F*.Rational Design of Esterase-Insensitive Fluorogenic Probes for InVivo Imaging.ACS Sens.2023.8,2041−2049.
23.Lin, Z B.; Zhao, Y.X.;Yang, W.C.*ABalancedMechanismBetweenPlantGrowth andStressResponse.Adv. Agrochem2023, 2,105–106.
24.Fu,Y.X.;Guo,W.Y.;Wang, N.; Dai,Y.J.;Zhang,Z.Y;Sun, X.L.;Yang, W.C.*;Yang, G.F.Diagnosis of Bacterial Plant Diseases via a Nitroreductase-ActivatedFluorescent Sensor.Anal. Chem.2022, 94,17692−17699.
25.Fu,Y.X.;Zhang,Z.Y;Guo,W.Y.;Dai,Y.J.;Wang, Z.Y.;Yang, W.C.*;Yang, G.F.*In Vivo Fluorescent Screening for HPPD-Targeted Herbicide Discovery. Pest Manag. Sci..2022,78,4947–4955.（Front cover）
26.Fu,Y.X.;Liu,S.Y;Guo,W.Y.;Liu,G.Z.;Dong, J.; Nan, J.X.;Lin, H.Y.;Mei, L.C.;Yang, W.C.*;Yang, G.F.*In vivo diagnostics of abiotic plant stress responsesvia in situ real-time fluorescence imaging. Plant Physiology.2022, 190,196−201.
27.Guo,W.Y.;Li, R.R.;Liu,S.Y;Fu,Y.X.;Liu,G.Z.;Yang, W.C.*;Yang, G.F.Pyroglutamate Aminopeptidase I Promotes Hepatocellular Carcinoma via IL-6/STAT3 Activation as Revealed by a Specific Biosensor. Anal. Chem.2021, 93,13311−13318.
28.Lin, H.Y.; Chen X.;Dong, J.;Ye,Y.;Xiao,H.; Zhan, C.G.;Yang, W.C.*; Yang, G.F.* Rational Redesign of Enzyme via the Combination of QuantumMechanics/Molecular Mechanics, Molecular Dynamics, andStructural Biology Study.J. Am. Chem. Soc.2021, 143,15674−15687
29.X. Wang, H. Lin, J. Liu et al., The structure of 4-hydroxylphenylpyruvate dioxygenase complexed with 4-hydroxylphenylpyruvic acid reveals an unexpected inhibition mechanism,Chin. Chem. Lett.,2021,32,1920−1924
30.Rajapaksha, A.A.; Fu,Y.X.;Guo,W.Y.; Liu,S.Y;Li,Z.W.;XiongC.Q.;Yang, W.C.*;Yang, G.F.Review on the recent progress in the development of fluorescent probes targeting enzymes.Methods and Applications in Fluorescence.2021,9,032001.
31.Guo,W.Y.;Fu,Y.X.; Liu,S.Y;Mei,L.C.; Sun, Y.;Yin, J.;Yang, W.C.*;Yang, G.F.*Multienzyme-TargetedFluorescent Probe as a Biosensing Platform for Broad Detection of Pesticide Residues.Anal. Chem.2021,93,7079−7085.
32.Qu, R.Y.; Yang, J.F.; Chen, Q.; Niu, C.W.; Xi, Z;Yang, W.C.*; Yang, G.F.*Fragment-based discovery of flexible inhibitor targeting wild-type acetohydroxyacid synthase and P197L mutant.Pest. Manag. Sci.2020,76,3403–3412.封面文章
33.Liu, S.Y.; Qu, R.Y.; Li, R.R; Yang, Y.C.; Sun, Y.;Yang, W.C.*;Yang, G.F.* An Activity-Based Fluorogenic Probe Enables Cellular and in Vivo Profiling of Carboxylesterase Isozymes.Anal. Chem.2020,92, 9205-9213.
34.Liu, S.Y.; Yan, A.M.; Guo, W. Y.; Fang, Y.Y.; Dong, Q.J.; Li, R.R; Ni, S.N.; Sun, Y.;Yang, W.C.*;Yang, G.F.* Human Neutrophil Elastase Activated Fluorescent Probe for Pulmonary Diseases Based on Fluorescence Resonance Energy Transfer Using CdSe/ZnS Quantum Dots.ACS Nano.2020,14, 4244-4254.
35.Liu, S.Y.; Xiong, H.; Li, R.R;Yang, W.C.*;Yang, G.F.* Activity-based Near-Infrared Fluorogenic Probe Enables In Vitro and In Vivo Profiling of Neutrophil Elastase.Anal. Chem.2019,91, 3877-3884.封面文章
【授权专利】
1.“High activity mutants of butyrylcholinesterase for cocaine hydrolysis” Zhan, C. G.; Zheng, F.; Yang, W. C. Patent #US7740840B1.已授权。
2.“High activity mutants of butyrylcholinesterase for cocaine hydrolysis” Zhan, C. G.; Zheng, F.; Yang, W. C. Patent #US7892537B1.已授权。
3.“High activity mutants of butyrylcholinesterase for cocaine hydrolysis” Zhan, C. G.; Zheng, F.; Yang, W. C. Patent #US 8206703.已授权。
4.“Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation”Zhao,Y.X.; Wu, S.;Yang, W. C.; He, Y.J.; Li, X.H.; Qiu, X.X. Patent #US 10618939.已授权。
5.香豆素衍生物及其制备方法以及弹性蛋白酶检测方法和检测试剂盒。杨光富，杨文超，李俊，孙琦，张春芳。专利号：201310086356.7，发明专利,中国，已授权。
6.蛋白水解酶活性的荧光检测方法。杨光富，杨文超，孙琦，李俊，刘万年。申请号：201310184727.5，发明专利,中国，已授权。
7.用于检测丁酰胆碱酯酶的荧光探针及其制备方法和应用。杨光富，杨文超，杨庶候。申请号：201611121637.1，发明专利,中国，已授权。
8.用于检测羧肽酶Y的荧光探针及其制备方法和应用。杨光富，杨文超，杨庶候。申请号：201611122778.5，发明专利,中国，已授权。
9.量子点荧光探针及其制备方法和应用以及检测弹性蛋白酶活性的方法和试剂盒。杨光富，杨文超，严爱民。申请号：201810306916.8，发明专利,中国。
