王贞超简介

【个人简介】

王贞超，女，理学博士，教授，博士生导师，主要从事化学生物学、药学、农药学等，开展具有医用农用活性的中草药源杂环先导化合物联合创制研究。相关研究工作已获多项基金项目支持，近年来以第一作者或通讯作者已发表学术论文61篇，授权专利8件。

邮箱：zcwang@gzu.edu.cn

【主持项目】

1.贵州省“第八批高层次创新型百层次人才”项目

2.国家自然科学基金委地区基金

3.“十四五”国家重点研发计划“子课题

4.贵州省企事业科协创新示范引领项目

5.贵州省“科技拔尖人才”项目

6.绿色农药与农业生物工程教育部重点实验室开放项目

7.贵州省科技厅基础研究重点项目

8.国家自然科学基金委青年基金

9.国家自然科学基金委地区基金

10.贵州省科技厅基础研究一般项目

11.贵州省“千层次创新人才”项目

12.贵州医科大学药用植物功效利用国家重点实验室开放基金项目

13.贵州省教育厅“青年科技人才成长”项目

14.贵州省科技厅基础研究一般项目

15.贵州大学博士基金项目

【学术论文】

1.Le, Y.#; Gan, Y. Y.#; Fu, Y. H.; Liu, J. M.; Li, W.; Xue, Z.; Zhou, Z. X.; Wang, Z. C.*; Ouyang G. P.; Yan, L. J.* Design, synthesis and in vivo biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment [J] Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35(1): 555−564.

2.Zhou, X.*; Liu, J. M.; Meng, J.; Fu, Y. H.; Wu, Z. B.; Ouyang, G. P.; Wang, Z. C.* Discovery of facile amides-functionalized rhodanine-3-acetic acid derivatives as potential anticancer agents by disrupting microtubule dynamics [J] Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36, 1996−2009.

3.Bai, N.#; Wang, X. C.#; Wang, Z. C.*; Liu, P. F.; Rong, Z. Q.* Redox-neutral remote amidation of alkenyl alcohols via long-range isomerization/transformation [J] Organic Chemistry Frontiers, 2022, 9: 5942–5948.

4.Zhu, M.; Li, Y.; Chen, D. P.; Li, C. P.; Ouyang, G. P.*; Wang, Z. C.* Allicin-inspired disulfide derivatives containing quinazolin-4(3H)-one as a bacteriostat against Xanthomonas oryzae pv. oryzae [J] Pest Management Science. 2023, 79: 537−547.

5.Zhang, W.; Guo S. X.; Wang, Y.; Tu, H.; Yu, L. J.; Zhao Z. C.; Wang Z. C.*; Wu, J.* Novel trifluoromethylpyridinepiperazine derivatives as potential plant activators [J] Frontiers in Plant Science. 2022, DOI 10.3389/FPLS.2022.1086057.

6.Zhang, G. L.#; Tang, Z. H.#; Fan, S. L.; Li, C. P.; Li, Y.; Liu, W. Q.; Long, X. S.; Zhang, W. J.; Zhang, Y.; Li, Z. R.; Wang, Z. C.*; Chen, D. P.*; Ouyang, G. P.* Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells [J] Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38(1): 2163393.

7.Zhang, G. L.; Li, C. P.; Li, Y.; Chen, D. P.; Li, Z. R.; Ouyang, G. P.*; Wang, Z. C.* Discovery and mechanism of azatryptanthrin derivatives as novel anti-Phytopathogenic bacterial agents for potent bactericide candidates [J] Journal of Agricultural and food chemistry, 2023, 71: 6288−6300.

8.Zhang, G. L.#; Li, C. P.#; Li, Y.; Chen, D. P.; Li, Z. R.; Wang, Z. C.* Ouyang, G. P.* Design, synthesis, and mechanism of novel 9‑aliphatic amine tryptanthrin derivatives against phytopathogenic bacteria [J] Journal of Agricultural and food chemistry, 2023, 71: 14232−14242.

9.Zhou, X. H.; Li, C. P.; Wang, W. X.; Zhang, F.; Zhou, Y.; Chen, D. P.*; Wang, Z. C.* DNAzyme mediated catalytic hairpin self-assembly strategy enables the sensitive and facile investigation of N6-methyladenine [J] Sensors and Actuators: B. Chemical, 2023, 397: 134665.

10.Wang, W. H.#; Li, Z. R.#; Zhu, D. X.; Chen, J. Y.; Zhou, Y.; Li, C. P.; Shao, L. H.; Qiu, X. M.; Zhu, M.; Long, H. T.; Chen, D. P.; Ouyang, G. P.; Rong, Z. Q.*; Wang, Z. C.* Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives [J] Pest Manag. Sci., 2024, DOI 10.1002/ps.7986.

【授权专利】

1.一类含哌嗪类结构衍生物及其应用.